This question is asked by many people, and the answer is yes, but usually in limited circumstances. Usually The IRS will not take a primary residence even if there is sufficient equity to pay the debt.
If you have more assets than the tax debt but enter into a payment plan, the IRS will not take investment properties either as long as you are working towards paying the debt.
If you are unsure about your situation, the best thing you can do is talk to a qualified tax attorney. For a free, no obligation consultation with a tax attorney apply for an appointment at our intake form.